The Many Benefits of Glutamine

What Is Glutamine?

Glutamine is the most abundant amino acid found in the human body. It plays a role in more metabolic processes than any other amino acid and is crucial for immune function, energy production, protein & glutathione synthesis, and antioxidant status. Sixty percent of glutamine is found in the muscle, making it the tissue with the highest concentration. The lung, liver, brain, and stomach also possess rich concentrations. Glutamine is not only the primary source of fuel used by our intestinal cells it’s a major fuel used by white blood cells. Although we can make glutamine, during times of stress (intense exercise, trauma, shock, illness, various disease states) the body’s need for glutamine rises sharply, surpassing our ability to produce it. These stressors have been shown to cause as much as a 50% drop in blood glutamine levels. Supplementation with glutamine powder has been shown to be a very effective way of countering this depletion and restoring glutamine to normal levels. These are some glutamine-rich foods one should consider incorporating into the diet; soy, sunflower seeds, Chinese cabbage, asparagus, eggs, meats, parmesan cheese, whey & spirulina.


Athletic Benefits

Athletes frequently use glutamine, and for a good reason. For those athletes that train intensely and often for prolonged periods, it’s been shown to assist in muscle cell repair, restore plasma glutamine levels, support immune function, and protect the digestive system. One of the challenges often facing hard training athletes is a condition known as exercise-induced immunosuppression. When training hard so much of one’s bodily resources are devoted to exercise that one’s immune function is compromised. This often results in infection, the most common one being upper respiratory. Immune function isn’t the only system affected; digestive disturbances are quite common. Acid reflux, diarrhea, abdominal cramping & even leaky gut have been shown to afflict many athletes.     


Non-Athletic Health Benefits

Aside from the numerous athletic specific benefits that glutamine has to offer it’s also been shown to provide a remarkable number of health benefits for the non-athlete:

            Intestinal Health

    • Increases intestinal villous height
    • Maintains mucosal integrity
    • Prevents intestinal hyperpermeability (aka leaky gut) possibly preventing sepsis (blood infection) n infection in the blood
      • Prevents bacterial translocation
    • One of the best supplements for treating gastrointestinal conditions like IBS, ulcerative colitis, Crohn’s, gastric ulcers and possibly diverticulitis
    • Reduces muscle wasting as well as normalizing intestinal permeability while improving intestinal absorption in individuals with HIV and Aids.


    • Can help trauma and surgery patients with their recovery
    • Reduces post-operative infections by nearly a half
    • Decreases the incidence of certain types of infections


    • Enhances liver detoxification
    • Glutathione (a powerful liver detoxifier and antioxidant) is made in the body from glutamine (glutamic acid), cysteine, and glycine.


    • Boosts immune function

           Weight Loss & Blood Sugar Regulation

    • May help reduce body weight and balance blood sugar and insulin levels
    • May stimulate growth hormone production


How much should I take and when?

The recommended dose is betwen 5 – 9 grams daily. If you exercise the ideal time to take it would be with your protein shake after your work out. If you don’t exercise it shouldn’t matter when you take it. For therapeutic use (like IBS) higher doses of 20 – 40 grams a day may be indicated.


What to look for in a quality glutamine Supplement?

Ensure you’re getting pure l-glutamine-free of artificial flavors, colors, sweeteners and genetically engineered ingredients. Ensure the l-glutamine is a free-form amino acid and not a glutamine peptide. Although glutamine peptides have been shown to work, they are typically sourced from wheat and may have trace amounts of gluten. L-glutamine that is made through the bacterial fermentation of vegetables will be free of gluten. Given the important gut benefits, this amino acid has to offer gluten free should be the obvious choice. Look for glutamine that is micronized. Micronization is a cutting-edge processing technology which breaks up regular l-glutamine into a micro-fine powder. This new micronized structure increases solubility allowing for better absorption.



1. Souba WW. Glutamine Physiology, Biochemistry, and Nutrition in Critical Illness. Austin, TX: R.G. Landes Co.; 1992.
2. Askanazi J, Carpenter YA, Michelsen CB, et al. Muscle and plasma amino acids following injury: Influence of intercurrent infection. Ann Surg 1980;192:78-85.
3. O'Dwyer ST, Smith RJ, Hwang TL, Wilmore DW. Maintenance of small bowel mucosa with glutamine-enriched parenteral nutrition. J Parent Enteral Nutr 1989;13:579-585.
4. Hwang TL, O'Dwyer ST, Smith RJ, et al. Preservation of small bowel mucosa using glutamine-enriched parenteral nutrition. Surg Forum 1987;38:56.
5. Li J, Langkamp-Henken B, Suzuki K, Stahlgren LH. Glutamine prevents parenteral nutrition-induced increases in intestinal permeability. J Parent Enteral Nutr 1994;18:303-307.
6. Barber AE, Jones WG, Minei JP, et al. Glutamine or fiber supplementation of a defined formula diet. Impact on bacterial translocation, tissue composition, and response to endotoxin. J Parent Enteral Nutr 1990;14:335-343.
7. Khan J, Iiboshi Y, Cui L, et al. Alanyl-glutamine-supplemented parenteral nutrition increased luminal mucus gel and decreased permeability in the rat small intestine. J Parent Enteral Nutr 1999;23:24-31.
8. Kanuchi O, Iwanaga T, Mitsuyama K. Germinated barley foodstuff feeding. A novel neutraceutical therapeutic strategy for ulcerative colitis. Digestion 2001;63:60-67.
9. Slotwinski R, Pertkiewicz M, Lech G, Szczygiel B. Cellular immunity changes after total parenteral nutrition enriched with glutamine in patients with sepsis and malnutrition. Pol Merkuriusz Lek 2000;8:405-408. [Article in Polish]
10. O'Flaherty L, Bouchier-Hayes DJ. Immunonutrition and surgical practice. Proc Nutr Soc 1999;58:831-837.
11. Jian ZM, Cao JD, Zhu XG, et al. The impact of alanyl-glutamine on clinical safety, nitrogen balance, intestinal permeability, and clinical outcome in postoperative patients; a randomized, double-blind, controlled study of 120 patients. J Parenter Enteral Nutr 1999;23:S62-S66.
12. Barbosa E, Moreira EA, Goes JE, Faintuch J. Pilot study with a glutamine-supplemented enteral formula in critically ill infants. Rev Hosp Clin Fac Med Sao Paulo 1999;54:21-24.
13. Castell LM, Poortmans JR, Newsholme EA. Does glutamine have a role in reducing infections in athletes? Eur J Appl Physiol Occup Physiol 1996;73:488-490.
14. Shabert JK, Wilmore DW. Glutamine deficiency as a cause of human immunodeficiency virus wasting. Med Hypotheses 1996;46:252-256.
15. Noyer CM, Simon D, Borczuk A, et al. A double-blind placebo-controlled pilot study of glutamine therapy for abnormal intestinal permeability in patients with AIDS. Am J Gastroenterol 1998;93:972-975.
16. Clark RH, Feleke G, Din M, et al. Nutritional treatment for acquired immunodeficiency virus-associated wasting using beta-hydroxy beta-methylbutyrate, glutamine, and arginine: a randomized, double-blind, placebo-controlled study. J Parenter Enteral Nutr 2000;24:133-139.
17. Klimberg VS, McClellan JL. Glutamine, cancer, and its therapy. Am J Surg 1996;172:418-424.
18. Ollenschlager G, Simmel A, Roth E. Availability of glutamine from peptides and acetylglutamine for human tumor-cell cultures. Metabolism 1989;38:S40-S42.
19. Moyer MP, Armstrong A, Aust JB, et al. Effects of gastrin, glutamine, and somatostatin on the in vitro growth of normal and malignant human gastric mucosal cells. Arch Surg 1986;121:285-288.
20. Fahr MJ, Kornbluth J, Blossom S, et al. Harry M. Vars Research Award. Glutamine enhances immunoregulation of tumor growth. J Parenter Enteral Nutr 1994;18:471-476.
21. van der Hulst RR, von Meyenfeldt MF, Deutz NE, Soeters PB. Glutamine extraction by the gut is reduced in patients with depleted gastrointestinal cancer. Ann Surg 1997;225:112-121.
22. Daniele B, Perrone F, Gallo C, et al. Oral glutamine in the prevention of fluorouracil induced intestinal toxicity: a double blind, placebo controlled, randomised trial. Gut 2001;48:28-33.
23. Yoshida S, Matsui M, Shirouzu Y, et al. Effects of glutamine supplements and radio-chemotherapy on systemic immune and gut barrier function in patients with advanced esophageal cancer. Ann Surg 1998;227:485-491.
24. Anderson PM, Ramsay NK, Shu XO, et al. Effect of low-dose oral glutamine on painful stomatitis during bone marrow transplantation. Bone Marrow Transplant 1998;22:339-344.
25. Brown SA, Goringe A, Fegan C, et al. Parenteral glutamine protects hepatic function during bone marrow transplantation. Bone Marrow Transplant 1998;22:281-284.
26. Ziegler TR, Bye RK, Persinger RL. Effects of glutamine supplementation on circulating lymphocytes after bone marrow transplantation: a pilot study. Am J Med Sci 1998;315:4-10.
27. Coghlin Dickson TM, Wong RM, Offrin RS, et al. Effect of oral glutamine supplementation during bone marrow transplantation. J Parenter Enteral Nutr 2000;24:61-66.
28. Schloerb PR, Skikne BS. Oral and parenteral glutamine in bone marrow transplantation: a randomized, double-blind study. J Parenteral Enteral Nutr 1999;23:117-122.
29. Journal of Nutrition. 2001;131:2578S-2584S.)
30. Nutrition. 2002 May;18(5):371-5.
31. Med Sci Sports Exerc. 2000 Jul;32(7 Suppl):S369-76.)
32. Opara, E.C., Petro A., et al. "L-glutamine supplementation of a high fat diet reduces body weight and attenuates hyperglycemia and hyperinsulinemia in C57BL/6J mice." J Nutr, 126: 273-79.




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